|
KMID : 1143120140040030149
|
|
Asia Pacific Allergy
2014 Volume.4 No. 3 p.149 ~ p.155
|
|
|
Reference ranges for induced sputum eosinophil counts in Korean adult population
|
|
Kim Mi-Yeong
Jo Eun-Jung
Lee Seung-Eun
Lee Suh-Young
Song Woo-Jung
Kim Tae-Wan
Hur Gyu-Young
Lee Jae-Hyung
Kim Tae-Bum
Park Heung-Woo
Chang Yoon-Seok
Park Hae-Sim
Min Kyung-Up
Cho Sang-Heon
|
|
|
Abstract
|
|
|
Background: Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults.
Objective: The purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults.
Methods: A total of 208 healthy nonasthmatic adults were recruited. Sputum induction and processing followed the international standard protocols.
Results: Adequate sputum samples were successfully collected from 81 subjects (38.9%). The upper 90 percentile for sputum eosinophil was calculated as 3.5%. The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, p=0.030). However, no significant correlations were found with age, gender, body mass index, smoking status, blood eosinophil, or fractional exhaled nitric oxide levels.
Conclusion: Current study was the first attempt to determine the reference ranges of induced sputum eosinophils in Korean adults. The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.
|
|
|
KEYWORD
|
|
|
Eosinophils, Sputum, Healthy volunteers, Reference values
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|